Workshop on Ion Channels, Thu, 11 Oct, 2007
Speaker: Clemens Heitzinger
Abstract
BioFETs (biologically sensitive field-effect transistors) are
field-effect biosensors with semiconducting transducers. Their device
structure is similar to a MOSFET, except that the gate structure is
replaced by an aqueous solution containing the analyte. Conductance
modulation of the transducer due to binding of the analyte to surface
receptors provides the detection mechanism. The main advantage of
BioFETs, compared to commercially available technology, is label-free
operation.
In this talk, we review recent experiments, mostly based on silicon
nanowire devices, that provide the motivation for this work. In these
experiments, DNA strands and tumor markers were detected. Despite
these successes, a quantitative theory to explain the functioning of
the biosensors and to fully understand the experiments was still
missing. The modeling of the sensors is complicated by the fact that
they consist of biomolecules and a nanoelectronic part with different
length scales.
We present our models for the quantitative analysis of BioFETs, which
are centered around a multi-scale model involving homogenized
interface conditions for the Poisson-Boltzmann equation. This
multi-scale model also provides the basis for self-consistent
simulations. Finally various simulation results from different models
and devices are compared to measurements to establish the validity of
our approach.
URL: www.ricam.oeaw.ac.at/specsem/ssqbm/participants/abstracts/index.php
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